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1996-02-27
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Document 0335
DOCN M9630335
TI Gamma delta T lymphocytes in human periodontal disease tissue.
DT 9603
AU Gemmell E; Seymour GJ; Department of Dentistry, University of
Queensland, Australia.
SO J Periodontol. 1995 Sep;66(9):780-5. Unique Identifier : AIDSLINE
MED/96098587
AB Gamma delta T cells have been implicated as playing a role in
inflammatory and autoimmune conditions. In this study, a
biotin-streptavidin peroxidase technique was used to determine the
presence of T cells expressing alpha beta and gamma delta T cell
receptors (TCR) in the inflammatory infiltrates of gingival tissue
sections from gingivitis and adult periodontitis patients. The lesions
were graded 1+ to 3+ according to the size of the infiltrate. alpha
beta+ T cells predominated in all infiltrates with no differences in the
mean percent (20 to 30%) according to size of lesion or to clinical
status. A mean percent gamma delta T cells of 0.42 +/- 0.11 and 0.91 +/-
0.42 was demonstrated in 1+ infiltrates of gingivitis and adult
periodontitis sections respectively. Although the mean percent gamma
delta T cells increased in both gingivitis (2.09 +/- 0.54) and adult
periodontitis sections (2.25 +/- 0.35) with increasing size of
infiltrate, this was not statistically significant. However, when the
mean proportion of gamma delta T cells of the total TCR bearing cells
was determined, there was a significant 3 to 4 fold increase in adult
periodontitis sections from 3.09 +/- 1.35 in 1+ lesions to 11.90 +/-
2.94 and 8.81 +/- 1.45 in 2+ and 3+ lesions respectively. A similar
increase of the same magnitude occurred in gingivitis sections from 2.82
+/- 0.74 in 1+ lesions to 11.12 +/- 4.13 in 2+ lesions, but this was not
significant (P = 0.055). There was no correlation between the increase
in the proportion of gamma delta T cells and the T:B cell ratio or the
CD4:CD8 ratio in individual lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
DE Adult B-Lymphocytes/IMMUNOLOGY/PATHOLOGY Cell Count Comparative Study
CD4-CD8 Ratio Gingival Hemorrhage/IMMUNOLOGY/PATHOLOGY
Gingivitis/IMMUNOLOGY/*PATHOLOGY Human Immunoenzyme Techniques
Periodontal Attachment Loss/IMMUNOLOGY/PATHOLOGY
Periodontitis/IMMUNOLOGY/*PATHOLOGY Receptors, Antigen, T-Cell,
alpha-beta/ANALYSIS Receptors, Antigen, T-Cell, gamma-delta/*ANALYSIS
Support, Non-U.S. Gov't T-Lymphocytes/IMMUNOLOGY/*PATHOLOGY
Tonsil/IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).